Analysis Of Aircraft Arrival Delay And Airport On-time Performance

While existing grid environments cater to specific needs of a particular user community, we need to go beyond them and consider general-purpose large-scale distributed systems consisting of large collections of heterogeneous computers and communication systems shared by a large user population with very diverse requirements. Coordination, matchmaking, and resource allocation are among the essential functions of large-scale distributed systems. Although deterministic approaches for coordination, matchmaking, and resource allocation have been well studied, they are not suitable for large-scale distributed systems due to the large-scale, the autonomy, and the dynamics of the systems. We have to seek for nondeterministic solutions for large-scale distributed systems. In this dissertation we describe our work on a coordination service, a matchmaking service, and a macro-economic resource allocation model for large-scale distributed systems. The coordination service coordinates the execution of complex tasks in a dynamic environment, the matchmaking service supports finding the appropriate resources for users, and the macro-economic resource allocation model allows a broker to mediate resource providers who want to maximize their revenues and resource consumers who want to get the best resources at the lowest possible price, with some global objectives, e.g., to maximize the resource utilization of the system

Detecting Periodic Patterns Of Arrival Delay

This study identifies the periodic patterns of arrival delay for non-stop domestic flights at the Orlando International Airport during 2002-2003. Cyclic variations in air travel demand and weather at the airport were observed and their consequent effects on flight delay were investigated. This study detected the frequencies of any regularly repeating delay patterns and then identified the factors associated with the detected frequencies of delay. These sequential tasks called the two-stage approach were performed using a mathematical frequency analysis and statistical analysis techniques. The results of the frequency analysis showed that arrival delay displayed daily, weekly and seasonal patterns of variation. The results of the statistical analysis showed that time of day, day of week, season, flight distance, precipitation at MCO and scheduled time intervals between successive flights were significantly correlated with arrival delay. © 2007 Elsevier Ltd. All rights reserved

Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan-Niwan Formula Treating Acute-on-Chronic Liver Failure

Background. Acute-on-chronic liver failure (ACLF) is a clinical syndrome with acute jaundice and coagulation dysfunction caused by various inducements on the basis of chronic liver disease. Western medical treatment is limited. Previous studies have confirmed that Jieduan-Niwan Formula (JDNW Formula), an empirical prescription for the treatment of ACLF, can inhibit inflammation and resist hepatocyte apoptosis. However, potential targets and mechanisms still need to be explored. Methods. In this study, network pharmacological analysis was performed to investigate the key components and potential mechanisms of JDNW Formula treating ACLF. Firstly, we predicted the potential active ingredients of JDNW Formula and the corresponding potential targets through TCMSP, BATMAN-TCM platform, and literature supplement. Then, the ACLF targets database was built using OMIM, DisGeNET, and GeneCard database. Based on the matching targets between JDNW Formula and ACLF, the PPI network was constructed for MCODE analysis and common targets were enriched by Metascape. Furthermore, the ACLF rat model was used to verify the potential mechanism of JDNW Formula in treating ACLF. Results. 132 potential bioactive components of JDNW Formula and 168 common targets were obtained in this study. The enrichment analysis shows that the AMPK signaling pathway was associated with the treating effects of JDNW Formula. Quercetin was hypothesized to be the key bioactive ingredient in JDNW Formula and has a good binding affinity to AMPK based on molecular docking verification. JDNW Formula and quercetin were verified to treat ACLF by regulating the AMPK/PGC-1α signaling pathway as a prediction. Conclusion. The study predicted potential mechanisms of JDNW Formula in the treatment of ACLF, involving downregulation of inflammatory factor expression, antioxidant stress, and inhibition of hepatocyte apoptosis. JDNW Formula may improve mitochondrial quality in ACLF via the AMPK signaling pathway, which serves as a guide for further study

Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation

Abstract The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections